Anabolic androgenic steroids (AAS) were initially created for therapeutic purposes, and synthetic derivatives of the male hormone testosterone. Due its great anabolic effects, these drugs are being used on a large scale, for the improvement of sports performance. In this present study, we aim to show the history of it’ use, present their mechanisms of action, more particularly its use correlate with improved body composition, muscle mass, aerobic capacity and verify their possible side effects, analyzing their use therapeutic and indiscriminate, through direct scientific research with the sports. Sources were reviewed scientific the following search engines: PUBMED, LILACS and SCIELO. The results showed that in presence of a suitable AAS and diet can contribute to increases in body weight, particularly lean body mass and muscle strength gains achieved by high intensity exercise, these effects can be further potentiated, the use of supraphysiological doses, but in the aspect of aerobic power, there are not scientific evidence to support their improvement. Regarding side effects, the use of AAS, is related to several complications in the liver, cardiovascular system, reproductive system and psychological characteristics, always assigned by the non-therapeutic and abuse of AAS. Thus we conclude that the use of AAS, are directly linked to gains muscle mass, strength, as well several side effects, always assigned to abusive and indiscriminate doses, it is noteworthy that the scientific literature, still has a certain lack of studies, mainly randomized, controlled, with supraphysiological doses in human, so many effects are still unknown.
Clomid is a SERM and works well for men with hypogonadism/testosterone replacement therapy (TRT)- both for men who wish to maintain fertility and for standard TRT. This medication is a classic part of Post Cycle Therapy (PCT). It has been shown more recently in the literature to be a useful agent to wean men off AAS World J Nephrol. 2015 May 6; 4(2): 245–253. Today, we are seeing many general physicians in America using Clomid and other ancillary agents like HCG to help reduce suffering and recover men diagnosed with anabolic steroid induced hypogonadism (ASIH). In addition to this, there is a place for AIs in the management of men on TRT. Some men who are on appropriate-dose physiologic testosterone replacement can manifest superphysiologic levels of estrogen, despite normal testosterone levels. Remember as discussed above, testosterone/estrogen balance is a multifactorial issue and some men simply have genes for becoming “out of balance” on TRT. When used in a very cautious and limited fashion, in men who have low heart disease risks- specifically normal HDL levels, the addition of a low dose AI to TRT can lead to improvements in quality of life via balancing androgen/estrogen levels. When this is done by an expert physician and the qualified patient is observed closely, symptoms of gynecomastia are rare as are adverse issues related to mood and sexual complaints. It’s all about balance and vigilance! Another very important point regarding TRT and superphysiologic levels of estrogen is the potential for breast cancer! The good news is that there is no definitive data indicating that TRT associated elevations of estrogen lead to breast cancer in men. I can tell you that this is something that any expert physician Rxing Testosterone to men has to think about and better have on his radar screen!!
Transdermal patches (adhesive patches placed on the skin) may also be used to deliver a steady dose through the skin and into the bloodstream. Testosterone-containing creams and gels that are applied daily to the skin are also available, but absorption is inefficient (roughly 10%, varying between individuals) and these treatments tend to be more expensive. Individuals who are especially physically active and/or bathe often may not be good candidates, since the medication can be washed off and may take up to six hours to be fully absorbed. There is also the risk that an intimate partner or child may come in contact with the application site and inadvertently dose himself or herself; children and women are highly sensitive to testosterone and can suffer unintended masculinization and health effects, even from small doses. Injection is the most common method used by individuals administering AAS for non-medical purposes.