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Size one opaque hard gelatin capsule shells were purchased from Capsugel. Dissolution was performed using USP Apparatus II (paddles), Model VK 7000 (Varian). Stand-alone UV–Vis spectrometer with diode array capacity, Model 8453, was from Agilent. Capsule sinkers (size 8/23) were from Sotax. SLS (reagent grade > 99%) was purchased from Fisher Scientific. Full flow cannula filters (10 µm) were from Quality Lab Accessories. Pepsin (800–2,500 units/mg) purified from porcine gastric mucosa was purchased from Sigma-Aldrich. All other chemicals were ACS grade or equivalent.