ONC1-0013B inhibits AR activity in vitro. A. ONC1-0013B structure. B. LnCAP cells cultured (10% CSS) for 3 days, then treated with tested compounds in presence of 1nM DHT for 1 day. PSA expression plotted as percentage of vehicle control (DMSO; n=2, mean±SEM). Ki values: ± (ONC1-13B), ± (MDV3100), (ARN-509). Mean±SEM from 5 replicate experiments (except ARN-509). C. LnCAP cells cultured (10% CSS) for 3 days, then treated with tested compounds in presence of 1nM DHT for 5 days. Viable cells plotted as percentage of vehicle control (DMSO; n=2, mean±SEM). IC50 values: 30nM (ONC1-13B), 148nM (MDV3100), 240nM (ARN-509). D. Competitive-binding assay vs AR ligand Fluormone™ (PolarScreen™ Androgen Receptor Competitor Assay). IC50 values: 19nM (DHT), (ONC1-13B), (MDV3100).
What is it? An anabolic/androgenic steroid altered to produce better muscle-building properties, making it very popular for bodybuilders.
How it’s taken: Tablets or injections
Brand names: Winstrol, although that brand is no longer in production in the United States.
Legalities: Regulated as a Schedule III drug, meaning a valid prescription is required for possession.
What it does: Promotes muscle growth. In the past, it has been prescribed for patients with osteoporosis, growth deficiencies and hereditary angioedema, a disease that causes swelling.
Side effects/risks: Oily skin, acne and hair loss. More severe risks include liver damage, cardiovascular strain, mood changes and hardening of the arteries.
In the news: Canadian sprinter Ben Johnson was stripped of his 1988 Olympic gold medal after testing positive for stanozolol.