It should be noted that in theory if one was to consistently suppress your natural estrogen levels for a long period of time, this would negatively impact your health, including your cholesterol. Due to the ability of Letrozole- to inhibit estrogen so much, this should definitely be a concern to most users. However the research that has focused on the relationship between use of letrozole and cholesterol levels is rather inconsistent in it's findings. Many studies have concluded that the compound is detrimental to both a user's HDL and LDL cholesterol levels, while other research has found no link. Obviously individuals are best served to monitor their cholesterol while using any compound via blood tests however barring that, letrozole should simply not be run for extended periods of time if at all possible. Doing so could cause serious medical complications.
Along with the issues related to blood lipids is the fact that many users complain that their libido is dramatically reduced when using the compound. This is related to the fact that estrogen is partly responsible for the regulation of an individual's sex drive. Since Letrozole- is so potent it can often drive estrogen levels too low and this inhibits a user's libido. To avoid this users can lower dosages, but some anecdotally report that even extremely low doses of the drug can cause problems. If this is the case a less potent compound such as exemestane or anastrozole may be a more appropriate option.
Hardy debuted in Total Nonstop Action Wrestling (TNA) on June 23, 2004, at the Second Anniversary Show , in a match against . Styles , for the TNA X Division Championship .  He also debuted his new entrance theme "Modest", a song performed by Hardy himself, and a new nickname, "The Charismatic Enigma".  The match ended in a no contest when Kid Kash and Dallas interfered.  Hardy returned to TNA on July 21 and was awarded a shot at the NWA World Heavyweight Championship .  Hardy challenged for the title on September 8, losing to NWA World Heavyweight Champion Jeff Jarrett .  In October 2004, he won a tournament,  earning a shot at the NWA World Heavyweight Championship on November 7 at Victory Road , TNA's first monthly pay-per-view.  Hardy was defeated by Jarrett once again in a ladder match at Victory Road following interference from Kevin Nash and Scott Hall .