Several brands of IVIG have been approved by the Food and Drug Adminsitration (FDA) (see table in Appendix). There is a lack of reliable evidence that any one brand of IVIG is more effective than other brands. However, immune globulin products may differ from each other in ways that may be important in a particular patient. Different manufacturers then use various combinations of precipitation and/or chromatography steps to obtain a final preparation that consists of greater than 95 % IgG in all currently available products. The various manufacturers also use different final purification steps and stabilizers to obtain their final products, which may then vary in storage requirement and shelf life. In several currently available products, stabilizers include sugars, such as sucrose, glucose, or maltose. Other products contain amino acids such as glycine and proline. The sodium content of different products also varies.
The CCRN exam is a 3 hour exam covering 150 multiple choice questions. The CCRN exams focus on three general populations: adult, pediatric and neonatal patients. Within the three general populations, the following subject categories are covered: Cardiovascular, Pulmonary, Endocrine, Hematology / Immunity, Neurology, Gastrointestinal, Renal, Multisystem, Behavior / Psychological and Professional Care and Ethical Practice. Each exam is age specific and a large percentage of each test focuses on clinical judgment. A smaller percentage of each test covers professional caring and ethical practice, which can address any age in the life span, in any of the tests.