During conventional pharmacologic dose corticosteroid therapy, ACTH production is inhibited with subsequent suppression of cortisol production by the adrenal cortex. Recovery time for normal HPA activity is variable depending upon the dose and duration of treatment. During this time the patient is vulnerable to any stressful situation. Although it has been shown that there is considerably less adrenal suppression following a single morning dose of prednisolone (10 mg) as opposed to a quarter of that dose administered every six hours, there is evidence that some suppressive effect on adrenal activity may be carried over into the following day when pharmacologic doses are used. Further, it has been shown that a single dose of certain corticosteroids will produce adrenal cortical suppression for two or more days. Other corticoids, including methylprednisolone, hydrocortisone, prednisone, and prednisolone, are considered to be short acting (producing adrenal cortical suppression for 1¼ to 1½ days following a single dose) and thus are recommended for alternate day therapy.
Went to a walk in doctor’s office bad cough phlegm told me my lung seemed clear what i fell to mention is that i breath in a lot of pollen when blowing off the roof she prescribed prednisone benzonatate fluticasone she wanted me to use these for a few days before I used the z pack she said if it didn’t get better then to use the z pack but I did use the Benzonatate for day 2 at a 100 mg and felt like the cough got worse so I took my 1st dose of the z pack tonight can I take the benzonatate and the z pack together I’m not really crazy about using the prednisone 20mg I’m a 57 year old male in good shape but I do take Lisinopril mg