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Glad to come across this! Just started Prednisolone 1% drops today -- EVERY HOUR for inflammation (possibly due to known MS or new uveitis) -- for ONE WEEK. Started feeling nauseous and went on line to see if it's a known side effect. I, too have yucky taste in sinus and throat. Found info that suggested placing and holding finger to inner corner of eye for 2 to 3 minutes after the drop to prevent "leaking" (in sinus cavity?) to reduce side-effects. I'm also drinking my go-to remedy for upset tummy-- green tea with ginger! Long week ahead :(
As a glucocorticoid , the lipophilic structure of prednisolone allows for easy passage through the cell membrane where it then binds to its respective glucocorticoid receptor (GCR) located in the cytoplasm. Upon binding, formation of the GC/GCR complex causes dissociation of chaperone proteins from the glucocorticoid receptor enabling the GC/GCR complex to translocate inside the nucleus. This process occurs within 20 minutes of binding. Once inside the nucleus, the homodimer GC/GCR complex binds to specific DNA binding-sites known as glucocorticoid response elements (GREs) resulting in gene expression or inhibition. Complex binding to positive GREs leads to synthesis of anti-inflammatory proteins while binding to negative GREs block the transcription of inflammatory genes.