Steroid-dependent nephrotic syndrome

Budesonide has a systemic clearance of approximately L/min in 4-6 years old asthmatic children. Per kg body weight children have a clearance which is approximately 50% greater than in adults. The terminal half-life of budesonide after inhalation is approximately hours in asthmatic children. This is about the same as in healthy adults. In asthmatic children treated with Pulmicort Turbohaler (800 μg single dose), plasma concentration reached Cmax ( nmol/L) at minutes after inhalation, and then decreased rapidly; AUC was nmol·h/L. The value for AUC is generally comparable to that observed in adults at the same dose, however, the Cmax value tends to be higher in children. Lung deposition in children (31% of the nominal dose) is similar to that measured in healthy adults (34% of nominal dose).

Steroid-dependent nephrotic syndrome

steroid-dependent nephrotic syndrome

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