Given YK11’s ability to significantly increase Follistatin production, along with its relatively weak activity at the androgen receptor, it’s likely that its myotrophic effects are mediated primarily through myostatin inhibition. If so, this would make YK11 a solid addition to just about any PED program, aside from those which already incorporate myostatin inhibitors. In my opinion, YK11 is one of the most interesting compounds to hit the market in recent years, but at this point most bodybuilders appear to be unaware, or at least unconcerned with its existence. I expect that to change in the days ahead, as we continue to learn more about it.
Of the reported cases of anaphylaxis attributed to Xolair, 39% occurred with the first dose, 19% occurred with the second dose, 10% occurred with the third dose, and the rest after subsequent doses. One case occurred after 39 doses (after 19 months of continuous therapy, anaphylaxis occurred when treatment was restarted following a 3 month gap). The time to onset of anaphylaxis in these cases was up to 30 minutes in 35%, greater than 30 and up to 60 minutes in 16%, greater than 60 and up to 90 minutes in 2%, greater than 90 and up to 120 minutes in 6%, greater than 2 hours and up to 6 hours in 5%, greater than 6 hours and up to 12 hours in 14%, greater than 12 hours and up to 24 hours in 8%, and greater than 24 hours and up to 4 days in 5%. In 9% of cases the times to onset were unknown.