Steroidmetabolitter

Methandrostenolone dose (amount and duration) and methods of isolation from urine can influence the identification and quantitation of methandrostenolone metabolites. Long-term use of methandrostenolone at high dosages led to the appearance of unmetabolized drug in the urine and contributed to the identification of a previously unreported metabolite, 3 beta, 6 section, 17 beta-trihydroxy-17 alpha-methyl-5 section-1-androstene. Exposure of methandrostenolone in vitro to acid conditions induced a retropinacol rearrangement in the D-ring of the methandrostenolone molecule, causing the formation of 18-nor-17,17-dimethyl-1,4,13(14)-androstatrien-3-one in large amounts. The same acidic conditions led to the addition of a hydroxyl at the 6 position of the B-ring of either the retropinacol rearrangement products or native methandrostenolone resulting in the formation of 6 beta-hydroxy-18-nor-17,17-dimethyl-1,4,13(14)-androstatrien-3-one, 6 alpha- hydroxy-18-nor-17,17-dimethyl-1,4,13(14)-androstatrien, 6 beta-17 alpha-methyl-1,4-androstadien-3-one and 6 alpha,17 beta-dihydroxy-17 alpha-methyl-1,4-androstadien-3-one. Hydroxylation of native methandrostenolone at the 6 position also occurs endogenously. However, no evidence of an endogenous retropinacol rearrangement was found. Silylating agents alone can induce the formation of small amounts of 6 beta-17 beta-dihydroxy-17 alpha-methyl-1,4-androstadien-3-one. Discrepancies between previously published reports on methandrostenolone metabolism in man are discussed and compared with an animal model.

Normalt er der et trade-off, hvor du kan få en testosteron boost fra nogle naturlægemidler ekstrakt kosttilskud, men som din mandlige hormon stiger, dine høje testosteron niveauer konvertere til østrogen og fordelene ved testosteron boost, som du havde håbet på forsvinder. Kroppen kan lide at forblive i homeostase - en slags testosteron status quo - hvorved dine forsøg på at sætte skub i testosteron naturligt er saboteret af din krop konvertere overskydende testosteron til østrogen og at sikre, at dit testosteron niveauer aldrig komme til eller overgå den høje ende af det normale testosteron interval. But this is not the case with Fadogia agrestis .

Steroidmetabolitter

steroidmetabolitter

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