Alpinia galangal Linn. Zingiberaceae: In rats with adjuvant-induced arthritis, administration of galangin (5, 10, 20 mg/kg) and MEAO significantly ((P<) suppressed the paw swelling, increased the paw withdrawal latency, and reduced the paw thickness. Diclofenac was taken as standard. Galangin (20mg/kg) and MEAO inhibited the increased level of serum lysosomal enzyme activity viz. aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phophatase (ALP). Galangin, MEAO exhibited anti-arthritic activity by improving the altered haematological parameters.
The aim of this article is to bring less well recognised adverse effects of inhaled corticosteroids to the attention of prescribers. Whilst inhaled steroids have a more favourable side effect profile than systemic steroids, they are not free from adverse effects. The dose of inhaled steroids used should be carefully monitored, and kept at the lowest dose necessary to maintain adequate control of the patient’s disease process. Be particularly aware of the cumulative effect of co-prescribing various dose forms of corticosteroids (inhaled, intranasal, oral and topical preparations).
The rationale for the use of vitamin D derivatives in the treatment of psoriasis is based on the observation that patients with hypocalcemia often develop various forms of psoriasis, most notably the pustular form. In one case, a patient who had undergone thyroidectomy developed repeated flares of pustular psoriasis after decreases were made in her dosage of ergocalciferol (Vitamin D 2 ); each episode was related to severe hypocalcemia and resolved after her serum calcium levels normalized. 14 Another patient with osteoporosis experienced dramatic improvement in severe psoriasis after receiving an oral form of vitamin D. 15 This finding, along with the discovery that the bioactive form of 1,25-dihydroxycholecalciferol has been shown to inhibit keratinocyte proliferation and promote keratinocyte differentiation, 16 has led to the development of vitamin D analogs for the treatment of psoriasis.